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OPIUM ADDICTION:  IX. WATER BALANCE STUDIES DURING THE ADMINISTRATION AND THE WITHDRAWAL OF MORPHINE

ARTHUR B. LIGHT, M.D.; EDWARD G. TORRANCE, M.D.
Arch Intern Med (Chic). 1929;44(5):693-699. doi:10.1001/archinte.1929.00140050070006.
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Abrupt withdrawal of morphine from human addicts is practically always associated with loss of weight during the manifestation of the so-called "withdrawal symptoms." During this period, the addicts invariably refuse to take any nourishment, their water intake is practically negligible and increased perspiration is noted. It is the object in this paper to report the results of our studies of water balance in five addicts, as well as in three normal persons, given the same diet, in order to determine whether the loss of weight is due entirely to inanition, or in part to an additional loss of water as the result of increased metabolism.

METHODS  Water balance was estimated by the method of difference of weight. The diet employed consisted of a modified Folin1 diet prepared each morning, the ingredients used being: eggs, whole milk, cream, malted milk, coffee, vanilla, Welch's grape juice and sugar, as well as 7

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