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RETICULOCYTOSIS PRODUCED BY LIVER EXTRACT:  TWO, THREE AND FOUR HOUR INTERVAL OBSERVATIONS

WILLIAM B. PORTER, M.D.; HAZELWOOD IRVING
Arch Intern Med (Chic). 1929;44(4):502-505. doi:10.1001/archinte.1929.00140040040004.
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During the past year and a half we have studied the response of patients with pernicious anemia to an aqueous extract of liver. This work has been conducted in conjunction with observers in three other clinics, so that a comparison could be made with the response to whole liver and to other liver extracts, to the end that an unbiased evaluation of its clinical worth might be established. The report of this work covers a study of forty-five patients with a macrocytic type of anemia.1 From a study of these patients, we conclude that liver extract E 292 produces results in every way similar to those which occur from the feeding of whole liver, except that the response is more prompt and rapid because the effective material from larger amounts of liver can be administered by this method.

Minot3 and his co-workers have established the fact that the most reliable

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