I recently reported a case of hyperpituitary disease with diabetes in which the efficacy of insulin was found to be impaired to a marked degree.1 Nearly all other authors have claimed, however, that acromegalic diabetes does not differ from pancreatic diabetes in the patient's response to treatment with insulin. I referred to some of them (John,2 Hetzel,3 Sachs and MacDonald,4 and Blum and Schwab5) and demonstrated that the evidence presented by them was inadequate to prove their claim.
Yater,6 in an article published simultaneously with mine, again attempted to show that insulin is in every respect as effective in acromegalic diabetes as it is in the pancreatic type. He reported three cases and cited Colwell,7 among others, in support of his contention.
It is my purpose here to show that a critical analysis of Yater's and Colwell's results and of the figures they publish does not yield such an interpretation