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PANCREATIC FUNCTION:  IV. THE HUMORONEURAL REGULATION OF THE GASTRIC, PANCREATIC AND BILIARY SECRETIONS

SEIZABURO OKADA, M.D.; KWANICHI KURAMOCHI, M.D.; TOSHIO TSUKAHARA, M.D.; TATSUO OOINOUE, M.D.
Arch Intern Med (Chic). 1929;43(4):446-471. doi:10.1001/archinte.1929.00130270020002.
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The regulatory mechanism of the secretion of the digestive juices was obscure until recently. Naunyn1 proved that puncture diabetes (Piqure diabetes) has an inhibitory influence on the secretion of bile. He attributed the inhibitory effect to the alteration of blood pressure in the liver. The classic experiments of Bayliss and Starling2 showed, in a striking way, that the secretory glands of the pancreas can be excited to activity through influences that reach them by humoral, as well as by nervous channels. They showed that when dilute acid acts on the duodenal mucosa, a substance, secretin, is formed that can accelerate the flow of pancreatic juice even when all nervous connections with the secretory gland are severed. They reach the conclusion that such a mechanism is involved normally in the production of pancreatic secretion. Edkins3 found that extracts of pyloric mucous membrane contain a substance that causes the secretion of a

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