Clinical jaundice is sometimes an accompaniment of duodenal ulcer when no other reason than the ulcer is apparent for its existence. Thus, it has been described as a symptom of duodenal ulcer by Reed,1 Ewald,2 Kemp,3 Schmidt4 and others. Usually it is described as a rare symptom5 but Collin6 found jaundice in nine of sixty-two cases of duodenal ulcer.
With the development of more exact methods of estimation of bilirubin in the blood, the question of possible jaundice in duodenal ulcer has become interesting. For, if clinical jaundice is present either as a rare symptom of ulcer or occurs in some series oftener than once in ten cases and, since the location of duodenal ulcer is fairly constant, it would seem possible that a certain proportion, possibly a large group, of patients with duodenal ulcer would show latent jaundice. If this is true, the interpretation of hyperbilirubinemia might be confusing