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THE EFFECT OF ROENTGEN RAYS ON THE HEART:  II. THE MICROSCOPIC CHANGES IN THE HEART MUSCLE OF RATS AND OF RABBITS FOLLOWING A SERIES OF EXPOSURES

ALDRED S. WARTHIN, M.D. Ph.D., LL.D.; ERNST A. POHLE, M.D., Ph.D.
Arch Intern Med (Chic). 1929;43(1):15-34. doi:10.1001/archinte.1929.00130240018002.
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In a previous article,1 we came to the conclusion that the single exposure of the precordium to roentgen rays of the quality and quantity described in that paper, and corresponding to a so-called human erythema dose, does not produce definite and irreparable injury to the heart muscles of adult rats and rabbits. The next step in these investigations suggested itself, i. e., the study of the effect of a series of exposures as they are carried out in the treatment of human beings. All malignant lesions in the region of the heart, for instance, mediastinal growth, carcinoma of the left breast, bronchus or a tumor of the lung are repeatedly treated at certain intervals with a single dose, varying from a part to a full tolerance dose. The latter term is used in preference to the "erythema dose," which implies a unit, but careful investigations have shown that it is

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