The purpose of this experimental study was (a) to produce a disturbance in a dog that parallels the clinical features of uremia; (b) to study the effects of such a disturbance on the gastro-intestinal canal, and (c) to arrive at a possible explanation of uremia on a chemical basis. As urea is the principal constituent of the urine, I naturally employed this metabolite as the uremia-producing substance.
Visceral disturbances in uremia are frequently so pronounced that the writers of the nineteenth century often referred to this condition as visceral uremia. The literature on this subject is profuse and at wide variance. I, therefore, will consider only a few references which deal directly with the problem.
REVIEW OF THE LITERATURE
The chemical theory of Wilson in 1833 ascribes uremia as due to the retention of urea in the blood stream. This theory met with considerable opposition and was primarily contested by