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Arch Intern Med (Chic). 1928;42(4):467-490. doi:10.1001/archinte.1928.00130210015002.
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  • Incidence of Scleroderma

  • Pathologic Process and Pathogenesis of Scleroderma

  • Incidence of Calcinosis

  • (a)Of Skin and Subcutaneous Tissues

  • (b) About Joints

  • Theories as to Pathogenesis of Calcinosis

  • Review of Cases in the Literature

  • Author's Case

  • Laboratory Observations

  • Comment

  • Summary

The subject of scleroderma has long been and continues to be one of pertinent interest, as evidenced by the vast amount of literature published on the subject during the past half century and even before. Similarly, the conditions resulting from disturbed or pathologic calcium metabolism have commanded increasing attention during recent years. The infrequent combination of these two interesting conditions, scleroderma and pathologic calcification, or calcinosis,1 is the unusual clinical problem I wish to present.The condition now termed scleroderma was not unknown to ancient medical men. Hippocrates, according to Bertolotti,2 described in his "Traités des epidémies," the case of a certain Athenian whose skin was so


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