This monograph is an excellent attempt to analyze and explain the deficient physiology of patients with cardiac lesions (valvular and myocardic) in the light of recent physiologic researches on circulation, on blood, and on muscle physiology, notably those of Henderson, Hill, Meyerhof, Barcroft and others. The monograph contains, in addition, a good deal of experimental work on patients by the authors themselves. Most of these experiments deal with the oxygen required in rest and under measured work by patients with cardiac deficiency as compared to normal human beings. The report in the majority of such patients is higher oxygen requirement during rest and a much higher oxygen requirement during work as compared to normal men. The authors endeavor to explain this deficiency by an upset in the lactic acid metabolism in the body muscles due to more or less chronic asphyxia.
The monograph deals with the following main topics in