As yet there is no universal agreement concerning the pathogenesis of the peptic ulcer which occurs spontaneously in man. Voluminous articles have been devoted to the effort to establish some causative factors, but the various theories and experimental reports have generally led rather to divergence than to convergence of ideas as to the particular etiologic agent.
It is true that ulcerations in the gastric and duodenal mucosa have been produced in various ways, but these experimental methods are usually so foreign to what could actually occur clinically that they can have little practical bearing on the etiology of the ulcer in man.
REVIEW OF THE LITERATURE
Ulcers of the stomach have been produced experimentally by interfering with nerve supply,1 by section of the spinal cord2 and by section or stimulation of the vagus or the sympathetic nerves. Durante3 and Vedova4 by such methods produced fairly well formed ulcers in a