In previous contributions from the Otho S. A. Sprague Memorial Institute, McClure and Aldrich1 reported work which demonstrated that the elevation2 made by intradermal injection of physiologic sodium chloride becomes impalpable more quickly in edematous and preedematous states than in the normal condition. Their reports dealt principally with edema associated with disturbances of the kidney in children, but also included several cases of cardiac disease and anemia.
Their studies of the edema with associated renal disturbance led them to favor the hypothesis that the edema in the type of case described is due to an intoxication of the tissues which causes them to take up and to hold more water than normally. They found the test of considerable value in indicating the prognosis in these cases.
Subsequently Baker3 used the test in the study of scarlet fever and diphtheria, and found it useful in indicating improvement or aggravation of these