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INTRAVENOUS INJECTION OF OUABAIN IN MAN

JOHN WYCKOFF, M.D.; WILLIAM GOLDRING, M.D.
Arch Intern Med (Chic). 1927;39(4):488-497. doi:10.1001/archinte.1927.00130040026003.
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During the past five years, in the third medical (New York University) division of Bellevue Hospital, we have been making controlled observations on the preparations, dosage, absorption and evidences of disappearance of the digitalis bodies in patients suffering from organic heart disease. Studies have been made, in conjunction with Eggleston1 and the Cornell medical division, on the absorption of digitalis when given by mouth, on the dosage and absorption of digitalis rectally administered and on the absorption and dosage of various preparations given hypodermically. We have found that absorption from the gastro-intestinal tract is so rapid and uniform, and when given in maximum dosage, complete digitalization takes place so promptly (within six to eight hours), that we have felt little practical need for giving the drug intravenously.

However, every physician is confronted from time to time with patients who, because of persistent vomiting due to the passive congestion caused by

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