Since the pioneer work of Jacobsen1 in studying the fluctuations in blood sugar levels following various types of meals, the general subject of carbohydrate metabolism has been the subject of many investigations. We shall not here attempt a proper consideration and evaluation of every published research and clinical comment, since there are a number of articles in which this service has been attempted, and a reference to the important features of these may for the present suffice.
The article of Folin and Berglund2 contains an excellent review of the general subject of carbohydrate metabolism from the point of view of the physiologic chemist. These authors conclude that the concept of renal threshold is absolutely true. They feel that the "glycuresis" described by Benedict, which, in brief, consists of readily demonstrable increases in sugar elimination too slight to give positive qualitative tests, is due to the excretion of nonutilizable carbohydrate bodies,