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ARTICLE |

THE PATHOGENESIS OF LIPOID NEPHROSIS

HERMAN ELWYN, M.D.
Arch Intern Med (Chic). 1926;38(3):346-359. doi:10.1001/archinte.1926.00120270069005.
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I. Lipoid nephrosis is a disease characterized by an insidious onset, a chronic course, edema, oliguria, albuminuria, changes in the protein and lipoids of the blood, and the deposit of lipoids in the kidney. It occurs alone, or in combination with diffuse glomerulonephritis, or with amyloid degeneration of the kidney.1

The disease thus characterized has gradually won for itself a place as a distinct clinical entity as a result of the work of numerous investigators during the last fifteen years. It is desirable to follow some of the steps in this development. The disease was formerly included under the term of chronic parenchymatous nephritis or the large white kidney. When one reads the description of chronic parenchymatous nephritis in Senator's2 work on diseases of the kidneys, it is evident that under this term are included the diseases that we have at present learned to separate into lipoid nephrosis and some

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