0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

PERNICIOUS ANEMIA, ACHYLIA GASTRICA AND COMBINED CORD DEGENERATION AND THEIR RELATIONSHIP

ROY R. GRINKER, M.D.
Arch Intern Med (Chic). 1926;38(3):292-302. doi:10.1001/archinte.1926.00120270015002.
Text Size: A A A
Published online

The first description of idiopathic anemia by Addison in 1855 and the subsequent work in 1872 by Biermer, who coined the term pernicious anemia, contained no mention of achlorhydria or combined cord degeneration. It was not until 1866 that Cahn and von Mehring1 first discovered the absence of free hydrochloric acid in the gastric juice in a case of pernicious anemia. Since then the relationship of achlorhydria and pernicious anemia has been recognized and of late has been the subject of considerable conjecture.

I propose to consider here this association of the gastric anacidity, the cord changes and the anemia, and it is hoped that by a survey of the literature and the study of some new material that the important known facts in this relationship may be summarized.

The absence of free hydrochloric acid in the gastric contents of pernicious anemias has been reported to be 100 per cent

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();