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ARTICLE |

THE RATE OF UREA EXCRETION AS A TEST OF RENAL FUNCTION BY MEANS OF A MODIFICATION OF McLEAN'S INDEX

SHOHEI KAWAHARA, M.D.
Arch Intern Med (Chic). 1926;38(1):36-40. doi:10.1001/archinte.1926.00120250041002.
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Although hitherto there have been several methods for testing renal function, few of them indicate accurately the ability of the kidney to excrete waste and metabolic end-products. The concentration and dilution tests are practical, and applicable for clinical purposes. It is possible to test the ability of the kidney to excrete foreign substances, such as phenolsulphonphthalein, lactose, potassium iodide and indigo carmine, but no one test will give equally satisfactory information in all cases of renal insufficiency, and the result differs according to the type of case. In a study of the elimination of substances normally excreted by the kidney the estimation of nitrogen, urea, chlorides and so forth, following the ingestion of an analyzed or calculated diet must be considered. The micromethods of Ivar Bang, the system of blood analysis of Folin and Wu, and the investigations of V. C. Myers are valuable in the determination of the concentration

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