The object of this investigation is to secure further information concerning the importance of oxygen as a therapeutic agent. In the first part of the paper, evidence will be presented bearing on the effectiveness of certain methods of administering oxygen; in the second part, a report will be made of the results of oxygen treatment by the more desirable of these methods.
Pharmacologic experience demonstrates that the therapeutic activity of a drug is closely related to the dosage employed. Such a conception, however, has had very little application to the therapeutic use of oxygen. Inefficient methods of administration and the absence of any precise knowledge as to how much oxygen the patient actually receives appear to be important factors accounting for the confusion surrounding the subject. It seems of value to define the limitations of a few commonly used methods and to inquire into the qualifications of an effective method,