Renal glycosuria is ordinarily accepted as a condition in which the kidneys are abnormally permeable to glucose. There is usually a constant though not necessarily high excretion of sugar in the urine which is practically uninfluenced by diet. The blood sugar remains at a normal or subnormal level and the symptoms of diabetes mellitus, even in cases that have lasted over a period of years, do not appear. It has also been generally supposed that the body retains its power to utilize and store carbohydrate in a normal manner. The only evidence so far offered that the latter supposition is true is that of Finley and Rabinowitch1 in a study of the gaseous metabolism of one case.
The present study gives the results of the administration of glucose on the respiratory quotient, total metabolism, blood sugar and glucose excretion in four cases of renal glycosuria. The technic employed in this