A detailed study is given of fifteen consecutive cases of pernicious anemia, one of hemolytic jaundice and one of aplastic anemia, and a review of ninety cases of pernicious anemia in the Leeds General Infirmary in the preceding ten years.
In the cases of pernicious anemia, the cord changes, achlorhydria and bone marrow changes are discussed in particular detail and the other features are adequately considered. The author concludes that itis caused by an infectious agent in the gastro-intestinal tract, occurring only in subjects with achlorhydria. This is contrary to American ideas, as some cases of advanced pernicious anemia may retain a practically normal gastric acidity.
Aplastic anemia, the author believes, belongs to a pathologic syndrome, occurring either secondarily to toxic factors or primarily. It bears no relation to pernicious anemia. It may occur in all grades of severity and may show equal or disproportionate deficiency in the three blood