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ARTICLE |

THE ALKALINE TIDE IN ACHLORHYDRIA

ROGER S. HUBBARD, Ph.D.; SAMUEL A. MUNFORD, M.D.
Arch Intern Med (Chic). 1925;35(5):576-585. doi:10.1001/archinte.1925.00120110042006.
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It has been generally believed that the changes in the reaction of urine which occur after a meal are due to the secretion of hydrochloric acid by the stomach and its subsequent reabsorption in the intestines. This view has been opposed by Hasselbalch1 and by Leathes,2 but has been supported by the more recent work of Campbell3 and Fiske.4 The earlier literature has been reviewed in these articles, in an article by us,5 and in a discussion of the acid-base balance by Wilson;6 therefore, it does not seem necessary to discuss it again at this time.

The method of fractional gastric analysis proposed by Rehfuss, Bergeim and Hawk,7 in 1914, has recently been subjected to criticism. Gorham,8 in 1921, first showed that there were marked differences in the acid content of samples of gastric juice obtained from different parts of the stomach, and questioned whether this should not make the

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