The incentive to the experimental work described here in detail was provided by the investigations of Valenti,1 in 1914. The work was actually begun in 1920 but, owing to circumstances over which we had no control, it was discontinued and resumed only in February, 1923.
A great deal of investigation has been carried on with morphin poisoning, and an excellent résumé has been presented by Du Mez.2 It is clear that the opinion regarding the action of this alkaloid and its manner of destruction, or at least its alteration, in the animal body is a matter of considerable dispute.
At the present time and, as a matter of fact, ever since the Harrison Act went into effect, the problem of drug addiction and of handling addicts has been of sufficient gravity to attract the attention of a large number of investigators. On account of the conditions brought about by the
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