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Arch Intern Med (Chic). 1925;35(4):433-456. doi:10.1001/archinte.1925.00120100031003.
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  • Introduction and definition of terms.

  • Gross and microscopic anatomy of the colon.

  • Physiology of the colon.

  • Clinical aspects of nonspecific ulcerative colitis.

    • Incidence.

    • Age.

    • Sex.

    • Mortality.

    • Residence.

    • Family history.

    • Occupation.

    • Previous illness.

    • Mode of onset.

    • Duration of symptoms.

    • Clinical picture.

  • Analysis of special symptoms and signs.

    • Diarrhea.

    • Character of stools.

    • Abdominal pain.

    • Abdominal tenderness.

    • Incontinence.

    • Vomiting.

    • Loss in weight.

    • Fever.

    • Sigmoidoscopic examination.

    • Blood changes.

    • Miscellaneous laboratory data.

  • Duration and course of nonspecific ulcerative colitis.

  • Prognosis.

  • Cause of death.

  • Operative findings.

  • Bacteriology of nonspecific ulcerative colitis.

  • Pathology of nonspecific ulcerative colitis.

  • Theories as to the etiology of nonspecific ulcerative colitis.

  • Treatment.

  • Conclusions.

INTRODUCTION AND DEFINITION OF TERMS  The subject of ulcerative colitis of unknown etiology has received comparatively little attention since the condition was first described by Wilks1 and White.2 Its prevalence and rapid spread in asylums in England at that time, particularly in those for the isane,


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