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THE PRODUCTION OF EXPERIMENTAL DIABETES INSIPIDUS

GEORGE M. CURTIS, M.D.
Arch Intern Med (Chic). 1924;34(6):801-826. doi:10.1001/archinte.1924.00120060064004.
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INTRODUCTION  The nature of that anomaly of metabolism known clinically as diabetes insipidus is not clear. One reason is its infrequency. Only fifteen cases were found in a recent study1 of the records of over 175,000 admissions to the Presbyterian Hospital. Statistics, largely from American hospitals, compiled by Williams2 give an incidence of about nineteen cases in each 100,000 admissions. It has been found difficult to hold patients suitable for metabolic study under extensive experimental observation.3 The condition is chronic, cases are usually ambulatory and there is not the fear of complications, such as the coma of diabetes mellitus. Thirst experiments especially are not well borne, owing to the severity of this symptom. An attempt to reproduce the disease experimentally in dogs has consequently seemed desirable.Polyuria, usually transient in character, has frequently been produced by experimental injury to different parts of the brain. Bernard4 noted polyuria subsequent to puncture

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