We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......


Arch Intern Med (Chic). 1924;34(5):714-720. doi:10.1001/archinte.1924.00120050131008.
Text Size: A A A
Published online

The purpose of this communication is (1) to discuss the errors introduced during the colorimetrie determination of phenolsulphonephthalein in the urine when the color of the dye is obscured by the bile pigments, and (2) to offer a method which permits of fairly accurate estimation of renal function, as expressed by the rate of excretion of phenolsulphonephthalein even though marked jaundice is present.

Rowntree and Geraghty1 noted in their paper, in 1910, that urinary and biliary pigments may be removed from urine by basic lead acetate. No details of the use of this substance were discussed. In 1921 a method was reported by Burwell and Jones,2 in which it was proposed that the use of a saturated alcoholic solution of zinc acetate precipitated both bile and blood pigments. The following paragraph is a quotation from the paper suggesting the use of zinc acetate.

Phenolsulphonephthalein is injected in the usual manner,


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview





Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.