At a meeting of the Association of American Physicians in May, 1923, Plummer1 reported on the use of iodin (compound solution of iodin) in the treatment of exophthalmic goiter. Iodin has been used in this disease by many in the past but has for the most part fallen into disrepute. Plummer, however, claimed striking benefit from its use. Following this suggestion we began shortly afterward the investigation which is reported in this paper. It is a continuation of the studies of various forms of therapy in exophthalmic goiter that have been made during the last ten years at the Massachusetts General Hospital.2 Our results seem to be similar to those obtained in the Mayo Clinic, which have been recently published by Plummer and Boothby.3
The chief effect is what may be called the iodin remission. Trousseau,4 in 1863, achieved this same result when he inadvertently gave a patient with exophthalmic
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