It is generally stated that disease of the gallbladder is associated with changes in gastric secretion. Most observers (Holweg,1 Rohde,2 Leva3 and Glaser,4 and recently Gatewood5) have found that hypoacidity and anacidity are present in cases of cholelithiasis and that similar findings are present after cholecystectomy. Other observers,6 however, have stated that hyperacidity and hypersecretion occur in cases of cholecystitis and in gallbladder disease associated with biliary retention. Thus Simnitsky7 found hyperacidity in obstruction of the common duct in man and animals.
These observations, particularly the alleged persistence of change in gastric secretion after cholecystectomy, led us to inquire into the relation of the gallbladder to the gastric secretory mechanism. Besides making a study of the effect of cholecystectomy on gastric secretion, we have studied the effect of bile on gastric secretion and have examined the mucosa of the gallbladder for the presence of a gastric secretin.