In recent years, the problem of chronic nephritis has become, to some extent, restricted to the question of chronic glomerulonephritis. This type of kidney disease is almost undoubtedly of toxic or infectious origin, and, therefore, some measure of prophylactic treatment should be possible. With human material, obtained at necropsy, it is extremely difficult to trace the origin and development of this progressive nephritis, chiefly because, at different stages, the kidney presents various gross and microscopic appearances, seemingly distinct conditions; hence, the origin of the numerous classifications seen in clinical and pathologic descriptions. Were it possible to reproduce experimentally in one of the lower animals a condition in the kidneys simulating the chronic glomerulonephritis seen in man, a vast field of useful study would at once be opened, and great progress would be made in our knowledge of an extremely common and serious pathologic entity.
I. REVIEW OF THE LITERATURE