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December 1923, Vol 32, No. 6 >
ARTICLE | December 1923

THE UREA CONCENTRATION FACTOR IN THE ESTIMATION OF RENAL EFFICIENCY

I. M. RABINOWITCH, M.D.
Arch Intern Med (Chic). 1923;32(6):927-938. doi:10.1001/archinte.1923.00110240120007.
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Results obtained by the application of the methods now in use in the study of renal function can, at best, show but an approximation of the truth, so far as the efficiency of the kidneys is concerned. The reason for this is obvious. The study of a pathologic reaction is the study of a disturbed physiologic reaction, and the exact physiology of the kidneys is far from perfectly understood. It is now well recognized that what we consider normal anatomic findings are not necessarily associated with normal functional findings, and vice versa. In the absence of certain specific renal stimulants or depressants, and by making the kidney excrete urea to its full capacity, Addis1 has shown that deductions can be made from functional findings as to the quantity of tissue present. This author and his co-workers2 have also shown that the kidney substance can excrete seven times the amount of

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