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ARTICLE |

THE BACTERIOPHAGE IN THE TREATMENT OF INFECTIONS

EARL B. McKINLEY, M.D.
Arch Intern Med (Chic). 1923;32(6):899-910. doi:10.1001/archinte.1923.00110240092005.
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It is premature to draw elaborate conclusions regarding the efficacy of the bacteriophage in the treatment of infections. However, we feel that our success in a number of cases is of sufficient importance to present these cases at this time.

The bacteriophage was found by d'Herelle1 in 1917 in the stools of patients convalescing from dysentery. The filtrates from broth cultures of these stools exhibited an interesting phenomenon. When added in amounts varying from 2 drops to 2 c.c. to young broth cultures of Shiga dysentery, it was found that these bacterial suspensions became limpid after a few hours in the incubator and were as clear as water. When agar slant subcultures were made from these tubes, after several hours' incubation one noted either a sterile slant (a pure culture of the bacteriophage) or multiple minute round clear areas in which no bacteria grew, and these d'Herelle has called "colonies"

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