An etiologic relationship between chronic foci of infection and systemic disease is accepted by most clinicians. The cure or marked improvement in some systemic disorder which may follow the removal of a septic focus seems conclusive proof of a causal relation. The clinical manifestations of focal infection depend primarily on the site of localization of the bacteria which are fed into the blood stream. The extent of clumping of the organism, the nature of the blood supply, the food supply and local tissue resistance must play important parts in determining the localization and resulting infection.
Rosenow1 has emphasized also the individual variation in bacteria and has advanced the theory that bacteria have a specific tendency to localize in certain tissues of the body, dependent on some peculiar inherent property. The theory is a most attractive one and has evoked a great deal of discussion. If it is true that bacteria