The chief disturbance associated with diabetes insipidus relates to water metabolism, and in any discussion of the subject the changes induced in normal persons by drinking water copiously must be kept in mind. Voit1 pointed out that there is a small increase in nitrogen elimination after copious water intake, although Straub2 found no effect on nitrogen equilibrium of man following the extra ingestion of 2 liters of water. Heilner3 found increased elimination of nitrogen in fasting dogs after the intake of 2 liters of water each day for two days. Hawk4 gave more water and less protein to human beings and found that 4,500 c.c. of water each day raised the urine nitrogen from 11.03 to 12.48 gm. on the first day, and to 11.82 gm. on the second day, with a secondary fall to 10.91 gm.
Rosenbloom and Price5 studied the metabolism of a boy, aged 4 years, suffering