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THE EFFECT OF ALKALIS ON GASTRIC SECRETION AND MOTILITY AS MEASURED BY FRACTIONAL GASTRIC ANALYSIS

BRUCE C. LOCKWOOD, M.D.; HAZEN G. CHAMBERLIN, M.D.
Arch Intern Med (Chic). 1923;32(1):74-81. doi:10.1001/archinte.1923.00110190077005.
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The object of this work was to determine by fractional analysis, in a sufficiently large number of persons, two points: (1) whether or not alkalis in addition to their immediate neutralizing effect also produce a secondary rise of acidity greater than that which occurs in a person without their administration; (2) what effect alkalis have on gastric motility.

Without extensively quoting the early literature on the subject, it is sufficient to state that there has always been a difference of opinion as to whether alkalis act as a stimulant or depressant to gastric secretion. The defenders of the alkaline Spa treatments held that while at times an alkali might act as a stimulant shortly after taking, the prolonged administration caused a gastric catarrh with associated decreased secretion. Those who believed that alkalis acted only as a depressor of gastric secretion were supported by Pawlow's observation1 that on a dog, soda

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