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November 1922, Vol 30, No. 5 >
ARTICLE | November 1922

THE DISTRIBUTION OF METABOLITES IN THE BLOOD AND TISSUES

HAROLD RYPINS, M.D.
Arch Intern Med (Chic). 1922;30(5):578-592. doi:10.1001/archinte.1922.00110110049006.
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INTRODUCTION  With the introduction of simple and reliable microchemical methods of analysis, the determination of the concentration of metabolites in the blood has become an accepted clinical procedure. Consequently, the relation of metabolites in the blood to their distribution throughout the entire organism is a subject of clinical as well as theoretic interest. I wish here to consider the distribution of metabolites in the body as a whole in relation to their concentration in the blood.Three methods have been applied in studying metabolite distribution. The first, which is used in this report, consists in parallel determinations of the metabolites in the blood and in the various body fluids. The second method consists in the postmortem analyses of tissues to determine their respective metabolite content. The third method is the study of the effect produced by the ingestion of a given quantity of meat, or urea, and the resultant changes

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