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August 1922, Vol 30, No. 2 >
ARTICLE | August 1922

STUDIES ON THE PHYSIOLOGY OF THE LIVER:  III. THE EFFECT OF ADMINISTRATION OF GLUCOSE IN THE CONDITION FOLLOWING TOTAL EXTIRPATION OF THE LIVER

FRANK C. MANN, M.D.; THOMAS BYRD MAGATH, M.D.
Arch Intern Med (Chic). 1922;30(2):171-181. doi:10.1001/archinte.1922.00110080041003.
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In previous studies on the physiology of the liver,1 a method of total extirpation of that organ and the effect of the removal on the sugar in the blood were recorded. Since, following removal of the liver the decrease in the blood sugar coincided so exactly with the development of the characteristic symptoms associated with the moribund condition, it was deemed highly possible that a causal relationship existed between the two. An investigation was made, therefore, of the effect of the administration of glucose on animals in which the liver had been removed.

In order to obtain the normal blood sugar value, a specimen of blood was taken from the jugular vein of a dog in which the first two stages of the operation had been completed. The liver was then removed conmpletely in the manner previously described, and close observations made. In many of the experiments the dog was

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