That there is an interrelation of the glands of internal secretion is well known. Rowntree1 states that where life is, metabolism is, and regulating it are the endocrine glands. Kestner2 states that all endocrine glands are closely related and that the most intimate relation exists between the thyroid and hypophysis. Engelbach3 mentions as a fact that the hypothyroid state is frequently associated with hypopituitarism. Peritz4 thinks that the intensive growth in length of bones which is sometimes found in exophthalmic goiter may be ascribed to a functional disturbance of the hypophysis. Holmgreen5 mentions that exophthalmic goiter patients in youth may show accelerated growth in height. Friedman6 believes that there may be a mild overactivity of the hypophysis in exophthalmic goiter and a mild underactivity in myxedema.
Numerous growth and feeding experiments give evidence of the relationship between the endocrine glands. Rogowitsch7 concluded that the changes in the hypertrophied hypophysis which