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Arch Intern Med (Chic). 1921;28(5):550-560. doi:10.1001/archinte.1921.00100170051003.
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INTRODUCTION  It has long been recognized that anemia and dropsy are common symptoms of the more severe forms of uncinariasis, and edema is usually a prominent feature in fatal cases. Subcutaneous edema, ascites, hydrothorax, and hydropericardium are commonly found, and a general anasarca sometimes occurs. It has been impossible to establish the relation between the presence of hookworms in the intestines and the nephritis suggested by the above symptoms by means of the limited methods of investigation heretofore employed; but albumin, casts, leukocytes and injured epithelial cells have been found in the urine, and typical lesions of chronic parenchymatous nephritis have been found at necropsy in patients who have died in an edematous state.The present study was undertaken to determine whether patients suffering from uncinariasis, and exhibiting edema, have any constant disturbance of renal excretory function, and whether this function is improved after anthelmintic medication. It had already been


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