Arch Intern Med (Chic). 1921;28(1):71-118. doi:10.1001/archinte.1921.00100130076007.
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Although John Bostock,1 in 1819, first described the symptom complex of hay-fever, it was not until 1873 that Blackley2 determined the real cause of the symptoms, namely, the pollen of plants. Curtis,3 in 1900, was the first to attempt to produce active immunity or to treat the condition; he used extracts of the whole plant. Since Dunbar,4 in 1905, was the first to employ extracts of the plant pollen, the modern treatment of hay-fever was really begun by him. During the past ten years reports on the treatment of hay-fever have been too numerous to justify reference to all of them in this paper, but the work of Noon, Freeman, Koessler, Cooke, Scheppegrell, Goodale, Selfridge and possibly of others justify the mention of their names since it is these who have done most toward establishing the treatment of seasonal hay-fever.

Notwithstanding the number of papers on the subject, there is


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