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April 1921, Vol 27, No. 4 >
ARTICLE | April 1921

STUDIES ON THE EFFECTS OF QUININ ON THE LIVER, BLOOD CELLS AND URINE OF RABBITS

DAVID M. SIPERSTEIN; MORRIS LITMAN
Arch Intern Med (Chic). 1921;27(4):449-456. doi:10.1001/archinte.1921.00100100065006.
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I. EFFECT OF QUININ ON THE LIVER  In the course of a series of observations on the excretion of bile pigments in the duodenum following the use of quinin, Prof, J. P. Schneider1 found that the bile pigments of the duodenal contents were markedly increased and that urobilinogen also appeared. He regarded this as an indication that the drug gave rise to pathologic changes in the liver. In a search of the literature we have been unable to find reference to any studies on the effect of quinin on the structure of the liver. The present investigation was, therefore, undertaken at his suggestion to determine whether pathologic changes in the liver could be induced in rabbits by the administration of doses of quinin comparable to those given in clinical practice or whether the drug gave rise to hemolysis in vivo.

MATERIAL AND METHODS  For the present investigation, fifteen healthy rabbits

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