Arch Intern Med (Chic). 1921;27(1):38-47. doi:10.1001/archinte.1921.00100070041002.
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Blood volume in pernicious anemia has been studied but little, and the results obtained have been at considerable variance. Of the literature concerning blood volume, only that portion bearing on pernicious anemia is considered in this paper. Various methods have been followed, such as the dye method of Keith, Rowntree and Geraghty,1 the carbon monoxid method of Haldane and Smith2 and those methods such as Quincke's3 and Lindeman's,4 based on the consideration of the red cells before and after transfusion. The dye method of Keith, Rowntree and Geraghty is based on the concentration in the blood of a dye injected intravenously which remains in the circulation for a long time. From this the plasma volume can be calculated and by the hematocrit readings the total blood volume determined. In three determinations made in cases of pernicious anemia they found the total volume in two to be decreased and in the


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