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Arch Intern Med (Chic). 1920;26(6):738-750. doi:10.1001/archinte.1920.00100060093005.
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In the chemical investigation of diabetes in the past, interest centered chiefly about the question of disturbed carbohydrate metabolism, especially its attendant manifestations of glycosuria and hyperglycemia. Although the fact that in diabetes there is an impaired metabolism of fats as well as carbohydrates has long been recognized, the study of this phase of the problem, by accurate chemical methods, was begun only a few years ago. A simple procedure for the determination of lipoids in human blood was described by Bloor,1 Joslin,2 Joslin, Gray and Bloor3 and Gray,4 who pointed out the significance of an increased concentration of fat in diabetic blood.5 Quite recently Brigham6 emphasized the importance of controlling hyperlipoidemia in the treatment of diabetes. He says, "until the fact concentration of the blood is reduced no progress in increasing a sugar tolerance can be made." Analytical data bearing on this point are still meager and it seems


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