During the past fourteen years, the work in this laboratory has been confined largely to a study of different types of acute experimental nephropathy and of certain naturally acquired chronic nephropathies. Four hundred and forty-nine animals have been employed in the various series of experiments. In a large number of these animals some form of renal functional test was used. In 132 animals a functional study of the kidney was the primary object of the investigation. In this latter group of animals a variety of functional tests were made use of. With this large amount of experimental data available, a study has been undertaken of the function of the kidney in different types of nephropathic processes and of the association of changes in the acid-base equilibrium of the blood with variations in the functional and pathological response on the part of the kidney.
In the earlier series of experiments1 which