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A STUDY OF RENAL FUNCTION AND THE ASSOCIATED DISTURBANCE IN THE ACID-BASE EQUILIBRIUM OF THE BLOOD IN CERTAIN EXPERIMENTAL AND NATURALLY ACQUIRED NEPHROPATHIES

WILLIAM deB. MacNIDER, M.D.
Arch Intern Med (Chic). 1920;26(1):1-7. doi:10.1001/archinte.1920.00100010004001.
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During the past fourteen years, the work in this laboratory has been confined largely to a study of different types of acute experimental nephropathy and of certain naturally acquired chronic nephropathies. Four hundred and forty-nine animals have been employed in the various series of experiments. In a large number of these animals some form of renal functional test was used. In 132 animals a functional study of the kidney was the primary object of the investigation. In this latter group of animals a variety of functional tests were made use of. With this large amount of experimental data available, a study has been undertaken of the function of the kidney in different types of nephropathic processes and of the association of changes in the acid-base equilibrium of the blood with variations in the functional and pathological response on the part of the kidney.

In the earlier series of experiments1 which

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