0
ARTICLE |

STUDIES OF THE CHEMISTRY OF PERNICIOUS ANEMIA

MAX KAHN, M.D., Ph.D.; JOSEPH BARSKY, M.D.
Arch Intern Med (Chic). 1919;23(3):334-345. doi:10.1001/archinte.1919.00090200067006.
Text Size: A A A
Published online

Squier1 has written an interesting and comprehensive review of the literature on the chemistry of pernicious anemia. Though a number of researches have been made on the pathochemistry of this very fatal disease, its causative factor is still unknown. Whether it is essentially a disease of the gastro-intestinal tract, with atrophy of the gastric mucosa and the absorption either of enterogenous poisons or protein split products, or whether it is a disturbance due to the hemolytic action of toxins elaborated in disease processes, or whether the disease is caused by hypersplenism, are the three main hypotheses in this mooted question.

The evidence brought forward by those authors who favor one or the other of these theories is not conclusive. A large number of chemical substances, such as oleic acid, saponins, phenylhydrazin, b-amino-azolyl-ethyl benzaldehyd, p-oxyphenylethylamin, etc., are violent hemolytic agents, and experimentally such poisons will produce anemia and hemoglobinuria, etc., but

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();