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ARTICLE |

THE STANDARDIZATION OF ANTIPNEUMOCOCCUS AND ANTIMENINGOCOCCUS SERUMS

AUGUSTUS B. WADSWORTH, M.D.; MARY B. KIRKBRIDE; RUTH GILBERT
Arch Intern Med (Chic). 1919;23(3):269-281. doi:10.1001/archinte.1919.00090200002001.
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During the latter part of 1916 the laboratory received reports indicating that some of the commercial antipneumococcus and antimeningococcus serums which had been purchased in the state lacked potency when used in the treatment of cases of pneumonia and meningitis.

Specific regulations for the standardization of diphtheria antitoxin were prescribed by an act of Congress in 1903, and following this, in 1907, the immunity unit for measuring the strength of tetanus antitoxin was officially defined and the method of standardization published. Since that time, and especially during the last four or five years, while the production of different immune serums such as are produced by immunization with the pneumococcus, streptococcus, meningococcus and the dysentery bacillus has been greatly extended, no federal regulations establishing standards of potency have been formulated for these serums. The federal license to sell these serums has been issued solely on the basis of an inspection of

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