Editor's Correspondence |

Tea and Coronary Heart Disease: Protection Through Estrogenlike Activity?

Johanna M. Geleijnse, PhD; Jacqueline C. M. Witteman, PhD; Lenore J. Launer, PhD; Stefan W. J. Lamberts, MD; Huibert A. P. Pols, MD
Arch Intern Med. 2000;160(21):3328-3329. doi:.
Text Size: A A A
Published online


Tea drinking appears to be protective against coronary heart disease in a number of epidemiologic studies. It has been suggested that tea flavonols with antioxidative activity, including quercetin, kaempferol, and myricetin,1 could account for the favorable effect on cardiovascular health.

In the older cohort of the Rotterdam Study, we observed an inverse association of tea drinking with severe aortic atherosclerosis.2 Interestingly, the relationship was most pronounced in women, which raised the hypothesis that an estrogen-related mechanism could be involved. Tea drinking in another population-based study of older women appeared protective against bone mineral loss, which may also indicate estrogenicity.3 Tea flavonoids such as kaempferol have indeed been shown to exhibit estrogenic activity in vitro.4 Daily kaempferol intake is almost doubled in regular tea drinkers compared with nondrinkers (a 6-mg increase for 3 to 4 cups of tea). In addition, tea contains lignan polyphenols, such as secoisolaracinol, which have been considered phytoestrogens.5 At present, however, it is not known whether the estrogenic activity of tea substances is biologically important.

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 20

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles