Editor's Correspondence |

Cholestatic Liver Reaction and Heparin Therapy

Roberto Manfredini, MD; Benedetta Boari, MD; François Regoli, MD; Massimo Gallerani, MD
Arch Intern Med. 2000;160(20):3166. doi:.
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Many drugs may lead to liver injury, including acute or cholestatic hepatitis. However, drug-induced hepatitis is often a presumptive diagnosis, as it is difficult to establish evidence of clear causal relationships between the use of certain drugs and liver damage. We report a case of cholestatic liver reaction associated with the use of heparin.

Not Available, Physicians' Desk Reference. 52nd ed. Montvale, NJ Medical Economics Co Inc1998;3044- 3045
Guevara  ALabarca  JGonzalez-Martin  G Heparin-induced transaminase elevations: a prospective study. Int J Clin Pharmacol Ther Toxicol. 1993;31137- 141
Olsson  RLeonhardt  T Cholestatic liver reaction during heparin therapy. J Intern Med. 1991;229471- 473
Capuano  GRodino  SD'Agostino  LBudillon  G Evaluation of heparin toxicity in the isolated and perfused rat liver. Enzyme 1986;3577- 81


heparin ; liver

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