0
Editor's Correspondence |

Hyperforin in Extracts of St John's Wort (Hypericum perforatum) for Depression—Reply

Barak Gaster, MD
Arch Intern Med. 2000;160(16):2546. doi:.
Text Size: A A A
Published online

Extract

In reply

Dr Cheng's comments regarding potential drug interactions with St John's wort are very important. Since the publication of our review, substantial evidence has arisen suggesting that St John's wort induces cytochrome p450, thereby potentially lowering the serum levels of many drugs. Those with a very narrow therapeutic window, such as the protease inhibitors used to treat human immunodeficiency virus infection, are of special concern.1 Regarding hyperforin, Hypericum extract contains at least 10 substances that have been shown to have biological activity, including hyperforin. Like hyperforin, several of these substances have been shown to bind neuroreceptors in the brain and to inhibit the uptake of various neurotransmitters thought to be involved in depression.

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
Jobs
JAMAevidence.com

The Rational Clinical Examination
Make the Diagnosis: Depression

The Rational Clinical Examination
Original Article: Is This Patient Clinically Depressed?

brightcove.createExperiences();