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Editor's Correspondence |

Successful Treatment of Massive Hemoptysis in Acute Leukemia With Recombinant Factor VIIa—Reply

Karina Meijer, MD; Willem E. de Graaff, MD; Simon M. G. J. Daenen, MD; Jan van der Meer, MD
Arch Intern Med. 2000;160(14):2216. doi:.
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Massive pulmonary bleeding due to invasive aspergillosis is often a fatal complication in patients with acute leukemia.1 We describe successful treatment with recombinant factor VIIa (rFVIIa) (Novoseven; Novo Nordisk, Copenhagen, Denmark) in a patient with this condition.

Pagano  LRicci  PNosari  A  et al.  Fatal haemoptysis in pulmonary filamentous mycosis: an underevaluated cause of death in patients with acute leukaemia in haematological complete remission: a retrospective study and review of the literature. Br J Haematol. 1995;89500- 505
Link to Article[[XSLOpenURL/10.1111/j.1365-2141.1995.tb08355.x]]
Baron  OGuillaume  BMoreau  P  et al.  Aggressive surgical management in localized pulmonary mycotic and nonmycotic infections for neutropenic patients with acute leukemia: report of eighteen cases. J Thorac Cardiovasc Surg. 1998;11563- 68
Link to Article[[XSLOpenURL/10.1016/S0022-5223(98)70443-X]]
Bernard  ACaillot  DCouaillier  JFCassasnovas  OGuy  HFavre  JP Surgical management of invasive pulmonary aspergillosis in neutropenic patients. Ann Thorac Surg. 1997;641441- 1447
Link to Article[[XSLOpenURL/10.1016/S0003-4975(97)00858-8]]
Hedner  U Recombinant activated factor VII as a universal haemostatic agent. Blood Coagul Fibrinolysis. 1998;9 ((suppl)) S147- S152
White  BMartin  MKelleher  SBrowne  PMcCann  SRSmith  OP Successful use of recombinant fVIIa (Novoseven®) in the management of pulmonary haemorrhage secondary to aspergillus infection in a patient with leukaemia and acquired fVII deficiency. Br J Haematol. 1999;106254- 255
Link to Article[[XSLOpenURL/10.1046/j.1365-2141.1999.01562.x]]
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