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Editor's Correspondence |

Gabapentin vs Amitriptyline for the Treatment of Peripheral Neuropathy

Jeffrey Fudin, PharmD; Christine M. Audette, PharmD
Arch Intern Med. 2000;160(7):1040-1041. doi:.
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We were disappointed by the article by Morello et al1 that was recently published in the ARCHIVES. It is our opinion that their discussion was misleading and their conclusions were iniquitous.

A total of 19 evaluable patients is not a sufficient number to arrive at any statistically significant conclusions in a double-blind study, especially with ordinal data. The authors admit that "260 patients per paired crossover study would be necessary to provide 80% power to detect a mean difference between treatments of approximately one third of the difference between mild and moderate pain at a .05 significance level." Nevertheless, the authors conclude that "mean pain diary and global pain relief score data indicate no statistical difference" between gabapentin and amitriptyline therapy in relieving pain.

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