In an intriguing study published in the ARCHIVES, Simonsen and colleagues1 conclude that observational studies have substantially overestimated influenza vaccination benefit in people 65 years and older. After adjusting for an aging US population and the frequency of influenza seasons in which the apparently more virulent influenza A(H3N2) subtype was dominant, they found that fewer than 10% of all winter deaths among people 65 years and older were attributable to influenza. That was not consistent with the meta-analysis estimate of vaccine effectiveness for all-cause mortality of 50% (45%-56%),2 which clearly suggests a much higher contribution of influenza as a cause of mortality.
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 3
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Users' Guides to the Medical Literature
Table 11.1-5 Influence of Age on Effect Size Estimates of Trials Evaluating the Efficacy of Vaccination in Preventing Influenza in Healthy Adults
The Rational Clinical Examination
Ten percent to 20% of US residents contract influenza annually, accounting for an average of...
All results at
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.