0
Editor's Correspondence |

Use of PPIs Are Not Associated With Mortality in Institutionalized Older People

Nicholas Wilson, MSc; Danijela Gnjidic, PhD; Lyn March, MD, PhD; Philip Sambrook, MD, PhD; Sarah N. Hilmer, MD, PhD
Arch Intern Med. 2011;171(9):866-867. doi:10.1001/archinternmed.2011.164.
Text Size: A A A
Published online

Extract

Bell et al1 published an insightful research letter in the Archives regarding the association of proton pump inhibitors (PPIs) and mortality among institutionalized older people. We wish to share the results of a similar analysis we conducted within a comparable population. We studied 602 participants from 51 different intermediate-level residential aged care facilities in Sydney, Australia, as part of a falls prevention study.2 At baseline, the mean (SD) age was 85.7 (6.4) years (range, 70-107 years), 70.9% were female, and 246 (40.9%) used a PPI. Over 1 year of follow-up, 62 participants (10.3%) died. The mortality rates were 11.0% (n = 27) and 9.8% (n = 35) among users and nonusers of PPIs, respectively (P = .37). There was similar use of nonsteroidal anti-inflammatory drugs (14.6% vs 12.4%; P = .42), low-dose aspirin (39.0% vs 32.6%; P = .10), and selective serotonin reuptake inhibitors (16.3% vs 13.2%; P = .29) among users and nonusers of PPIs. We observed no difference in mortality between users and nonusers of nonsteroidal anti-inflammatory drugs (10.0% vs 10.3%; P = .93), low-dose aspirin (11.3% vs 9.7%; P = .54), or selective serotonin reuptake inhibitors (6.9% vs 10.9%; P = .26). Adjusted Cox proportional models, similar to those used in the aforementioned study and shown in the Table found no association of PPI use with 1-year mortality (hazard ratio, 1.08; 95% confidence interval, 0.63-1.86).

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles
Jobs
JAMAevidence.com


Mortality

brightcove.createExperiences();